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KMID : 1130620140100010069
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Journal of Clinical Neurology
2014 Volume.10 No. 1 p.69 ~ p.71
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Myasthenia in Acquired Neuromyotonia
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Byun Jung-Ick
Moon Hye-Jin
Hong Yoon-Ho
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Abstract
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Background: Acquired neuromyotonia (NMT) forms part of the spectrum of acquired peripheral nerve hyperexcitability syndrome, and is thought to be caused by antibodies to voltage-gated potassium channels (VGKC). Exertional weakness is unusual unless autoimmune myasthenia gravis (MG) is superimposed.
Case Report: A case of acquired NMT accompanied by exertional weakness without coexistence of seropositive MG is reported herein.
Conclusions: Clinical and electrophysiological observations suggest that the cholinergic overactivity in NMT can compromise the safety factor sufficiently to cause a defect in neuromuscular junction transmission.
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KEYWORD
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neuromyotonia, myasthenia, neuromuscular junction
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